Few data exist regarding treatment with antipsychotics in forensic psychiatric patient populations with high social dangerousness. We performed a secondary analysis of 681 patients treated with at least one antipsychotic, extracted from a 1-year observational retrospective study, conducted on 730 patients treated in the Italian Residencies for Execution of Security Measures. We aimed at investigating antipsychotic polypharmacy and high dose/very high-dose antipsychotics, as well as the possible factors associated with such therapeutic regimens. High dose/very high-dose antipsychotics were defined as a (...) prescribed daily dose to WHO-defined daily dose ratio greater than 1.5 or 3.0, respectively. Binary logistic regression analysis was used in three models to test possible predictors of antipsychotic polypharmacy, high-dose antipsychotics, and very high-dose antipsychotic prescription. Antipsychotic polypharmacy resulted in n = 308 of the patients, n = 346 received high-dose antipsychotics, and n = 96 very high-dose antipsychotics. The multivariate analysis disclosed an association between antipsychotic polypharmacy and male gender : 2.75 and 95% CI: 1.34–5.65), long-acting injectable antipsychotic prescription, and aggressive behavior in REMS. High-dose antipsychotics were also associated with male gender, LAI antipsychotic prescription, and aggressive behavior in REMS. The use of antipsychotic polypharmacy and high-dose antipsychotics is frequent in the REMS population. These results might depend on regulatory and organizational aspects of the REMS system, including variability in structures, lack of a common model of care, and lack of stratified therapeutic security. (shrink)

Every organization has to deal with operational risks, arising from the execution of a company’s primary business functions. In this paper, we describe a legal knowledge management system which helps users understand the meaning of legislative text and the relationship between norms. While much of the knowledge requires the input of legal experts, we focus in this article on NLP applications that semi-automate essential time-consuming and lower-skill tasks—classifying legal documents, identifying cross-references and legislative amendments, linking legal terms to the most (...) relevant definitions, and extracting key elements of legal provisions to facilitate clarity and advanced search options. The use of Natural Language Processing tools to semi-automate such tasks makes the proposal a realistic commercial prospect as it helps keep costs down while allowing greater coverage. (shrink)

Every organization has to deal with operational risks, arising from the execution of a company’s primary business functions. In this paper, we describe a legal knowledge management system which helps users understand the meaning of legislative text and the relationship between norms. While much of the knowledge requires the input of legal experts, we focus in this article on NLP applications that semi-automate essential time-consuming and lower-skill tasks—classifying legal documents, identifying cross-references and legislative amendments, linking legal terms to the most (...) relevant definitions, and extracting key elements of legal provisions to facilitate clarity and advanced search options. The use of Natural Language Processing tools to semi-automate such tasks makes the proposal a realistic commercial prospect as it helps keep costs down while allowing greater coverage. (shrink)

This paper describes the Eunomos software, an advanced legal document and knowledge management system, based on legislative XML and ontologies. We describe the challenges of legal research in an increasingly complex, multi-level and multi-lingual world and how the Eunomos software helps users cut through the information overload to get the legal information they need in an organized and structured way and keep track of the state of the relevant law on any given topic. Using NLP tools to semi-automate the lower-skill (...) tasks makes this ambitious project a realistic commercial prospect as it helps keep costs down while at the same time allowing greater coverage. We describe the core system from workflow and technical perspectives, and discuss applications of the system for various user groups. (shrink)

Il saggio propone alcune osservazioni a margine delle tre lezioni tenute dal giudice federale statunitense Guido Calabresi a Macerata nel 2012. Le lezioni riguardano l'organizzazione delle corti di giustizia federale negli Stati Uniti, la forma e il ruolo delle sentenze giudiziarie all'interno di un sistema federale e il rapporto che intrattiene con la pena di morte un giudice a essa decisamente contrario. Secondo Melis queste lezioni restituiscono in maniera straordinariamente viva e precisa la struttura del sistema giudiziario e, al (...) tempo stesso, l'esperienza soggettiva di un giudice. (shrink)

The automated identification of national implementations of European directives by text similarity techniques has shown promising preliminary results. Previous works have proposed and utilized unsupervised lexical and semantic similarity techniques based on vector space models, latent semantic analysis and topic models. However, these techniques were evaluated on a small multilingual corpus of directives and NIMs. In this paper, we utilize word and paragraph embedding models learned by shallow neural networks from a multilingual legal corpus of European directives and national legislation (...) to develop unsupervised semantic similarity systems to identify transpositions. We evaluate these models and compare their results with the previous unsupervised methods on a multilingual test corpus of 43 Directives and their corresponding NIMs. We also develop supervised machine learning models to identify transpositions and compare their performance with different feature sets. (shrink)

The automated identification of national implementations of European directives by text similarity techniques has shown promising preliminary results. Previous works have proposed and utilized unsupervised lexical and semantic similarity techniques based on vector space models, latent semantic analysis and topic models. However, these techniques were evaluated on a small multilingual corpus of directives and NIMs. In this paper, we utilize word and paragraph embedding models learned by shallow neural networks from a multilingual legal corpus of European directives and national legislation (...) to develop unsupervised semantic similarity systems to identify transpositions. We evaluate these models and compare their results with the previous unsupervised methods on a multilingual test corpus of 43 Directives and their corresponding NIMs. We also develop supervised machine learning models to identify transpositions and compare their performance with different feature sets. (shrink)

This article seeks to address the problem of the ‘resource consumption bottleneck’ of creating legal semantic technologies manually. It describes a semantic role labeling based information extraction system to extract definitions and norms from legislation and represent them as structured norms in legal ontologies. The output is intended to help make laws more accessible, understandable, and searchable in a legal document management system.

Current climate change has raised concerns over the fate of the stenothermal Antarctic marine fauna (animals that evolved to live in narrow ranges of cold temperatures). The present paper focuses on Notothenioidei, a taxonomic group that dominates Antarctic fish. Notothenioids evolved in the Southern Ocean over the last 20 million years, providing an example of a marine species flock with unique adaptations to the cold at morphological, physiological and biochemical levels. Their phenotypic modifications are often accompanied by ‘irreversible’ genomic losses (...) or gene amplifications. On a micro‐evolutionary scale, relatively ‘shallow’ genetic variation is observed, on account of past fluctuations in population size, and a significant genetic structure is evident, suggesting low population connectivity. These features suggest that Antarctic fish might have relatively little potential to adapt to global warming, at least at a genetic level. The extent of their phenotypic plasticity, which is evident to some degree, awaits further research. (shrink)

Current climate change has raised concerns over the fate of the stenothermal Antarctic marine fauna (animals that evolved to live in narrow ranges of cold temperatures). The present paper focuses on Notothenioidei, a taxonomic group that dominates Antarctic fish. Notothenioids evolved in the Southern Ocean over the last 20 million years, providing an example of a marine species flock with unique adaptations to the cold at morphological, physiological and biochemical levels. Their phenotypic modifications are often accompanied by ‘irreversible’ genomic losses (...) or gene amplifications. On a micro‐evolutionary scale, relatively ‘shallow’ genetic variation is observed, on account of past fluctuations in population size, and a significant genetic structure is evident, suggesting low population connectivity. These features suggest that Antarctic fish might have relatively little potential to adapt to global warming, at least at a genetic level. The extent of their phenotypic plasticity, which is evident to some degree, awaits further research. (shrink)

Dalla Prefazione di Manfred Frings: «Il libro di Guido Cusinato non solo riesce a mettere in evidenza la molteplice rilevanza della filosofia di Scheler […], ma illumina anche nuovi aspetti e apre nuove prospettive di indagine. Questo obiettivo viene raggiunto da Cusinato con rigore metodologico e attraverso uno sforzo teso a verificare tutta una serie di affermazioni che erano state fatte finora in modo forse un po’ troppo affrettato. Per es. dimostra che Scheler non era né un dualista né (...) un panteista, come invece spesso si è sostenuto […] Cusinato offre al lettore elementi finalmente efficaci per rivedere parecchi luoghi comuni. In particolare Cusinato ritiene importante, mettere da parte quella categoria interpretativa del “dualismo” fra spirito e vita, che così spesso è stata invece applicata alla sua metafisica. Al suo posto Cusinato suggerisce di intendere la concezione scheleriana della relazione fra spirito e vita, o meglio, fra spirito e pulsione (Geist e Drang), facendo ricorso ad un termine che compare negli ultimi scritti: quello di interpenetrazione (Durchdringung). […] Fra le analisi che Cusinato svolge […] le più preziose e originali mi sembrano essere quelle relative all’umiltà (Demut). Invece nella maggior parte della letteratura su Scheler l’umiltà, uno dei tre atti morali fondamentali per accedere all’atteggiamento filosofico, non viene neppure menzionata. L’interpretazione che ne dà Cusinato, ponendola a fondamento di una «riduzione catartica» pensata in contrasto con la consueta riduzione husserliana, offre senz’altro spunti promettenti per le indagini future» (M. S. Frings, Prefazione, in: G. Cusinato, Katharsis, pp. 6-7). (shrink)

Il tema del soggetto e dell’identità è uno dei più importanti della filosofia moderna e la destrutturazione di esso il tratto tipico di molta filosofia europea di fine ’800 e inizio ’900. Si pensi alla scuola del sospetto, come la definì Paul Ricœur, ovvero a Nietzsche, la psicanalisi ed al marxismo, ma anche, più recentemente, al post-strutturalismo. Successivamente l’argomento, dalla fine del postmoderno in poi, è stato trattato sempre meno in ambito continentale. È invece diventato sempre...

In Italy a specific legislation on administrative management has been belated and its rhetoric showed to be in contradiction with its practical translation. The relationship between management and politics has been characterized either by an excessive distance or by a pathological proximity or else by indifference towards the ends of the policies that the management should have interpreted. The senior civil service has thus self-excluded from the national elites and it has never really mobilized in the decisional spheres of the (...) country. The essay analyzes, through four periodizing dates, the transformations of the senior civil service and its relationship with the political power in the 150 years of history since the unity of Italy. (shrink)

Botticelli and Tizian depict the Annunciation in two very different ways. Botticelli portrays a kneeling angel in an act of guiding from below, while Tizian represents an angel imposing himself from above with an authoritarian forefinger. Botticelli's painting suggests an intention of orientation that is not authoritarian yet able to bring about a transformation (Umbildung). It also suggests that an individual's transformation cannot be achieved in a closed solipsistic dimension, but requires a disclosure from otherness. My theory is that at (...) the origin of ethics there is a non-authoritarian way of orientation that comes from otherness and arises from the emotional sphere thanks to a "care of desire". The expression cura sui has often been interpreted as a care confined to a private and solipsistic dimension with the aim of strengthening the self-referential subject. By "care of desire" I mean a care not turned upon itself but made possible by a disclosure coming from otherness and addressed to the transformation of the individual and of society. In the human existence, emotions reveal an extraordinary plasticity. They are not already regulated by instinct but develop and get to maturity even many years after biological birth. Moreover, this maturation process does not follow a universal process identical for everyone, being different for every individual. In fact it finds its realization in the unique order of feelings (ordo amoris) that characterizes every individual. Emotions guide actions and the way we interact with the others and with the world. In the human existence they become plastic and don't have only a homeostatic function of self-regulation. They give flexibility to our way of perceiving, of existing and of taking our position in the world. The care of desire is dedicated to the plasticity of emotions and makes ethics, i.e. a person's formation process (Bildung) and flourishing, possible. It also allows the transition from the “environmental closedness” (Umweltgeschlossenheit) to the world-openness (Weltoffenheit). To sum up, the care of desire implies the transition from a solipsistic self-care to a “care for world-openness”. From this point of view, emotion is no more the secondary result of a cognitive process, but at the origin of every formative, perceptive and cognitive process: In the beginning was the emotion. Yet in this process of creative transformation not every emotion has the same significance: at the core of emotions’ plasticity there are love and wonder (thaumàzein), whose peculiar feature is “lack of envy” (aphthonoi). (shrink)

In questo lavoro si dimostra che l'opinione comune, secondo cui è Heidegger a introdurre Jacob von Uexküll nel dibattito filosofico è scorretta, in quanto è Scheler, due decenni prima, a scoprire e valorizzare la portata filosofica di Uexküll. -/- Pure la distinzione fra mondo (Welt) e ambiente (Umwelt), come quella fra apertura al mondo e chiusura ambientale, non è introdotta da Heidegger nel 1929 (cfr. l'Introduzione di Marco Mazzeo al testo di Uexküll, Ambienti animali e ambienti umani, p.18 e seg.) (...) ma è già presente in Scheler negli scritti del periodo 1909-1913. (shrink)

Scheler, like Jaspers, gives a key importance to the relations with alterity and grounds both the individual formation and social ontology on the practices of “sharing emotions”. My work attempts to interpret the impairments related to the capacities of communication – that Jaspers places at the roots of psychopathology and that the Japanese psychiatrist Bin Kimura has more recently argued to be the core of schizophrenia – as impairment of what Scheler calls ordo amoris, that is the “order of feeling” (...) of a person: like a "Psychopathology of the Ordo Amoris". (shrink)

In this paper, I argue that the concept of ecstasy (Ekstase), which Schelling elaborates on starting from the Erlanger Vorträge, is his response to Hegel’s famous «shot from a pistol». With this concept, Schelling overcomes the notion of «intellectual intuition», which was at the core of Hegel’s critics, and can now conceive the preeminence of existence (in the sense of Freudigkeit der Existenz) over Being (Sein). Thus, the theory of ecstasy puts Schelling beyond German Idealism and, under some aspects, allows (...) for a post-Heideggerian reading of his philosophy. (shrink)

Ha scritto Adorno: «la verità hegeliana non è più nel tempo, come era quella del nominalismo, e non è al di sopra del tempo, alla maniera ontologica: il tempo diventa per Hegel un suo momento». Un movimento complesso intreccia e separa l’eternità del Concetto dalla sua realtà temporale: la comprensione più precisa di questo rapporto resta una chiave di interpretazione fondamentale dell’idealismo hegeliano. Di questo problema la Fenomenologia dello Spirito offre un'immagine indicativa: racconta l’innalzamento della coscienza naturale fino al Sapere (...) Assoluto, che trascende il tempo. Il presente studio scorge nella memoria il motore di questa progressione: analizzando anche gli altri testi jenesi, l’autore ricostruisce la capacità speculativa della memoria, in grado di trasformare il passato temporale nel passato senza tempo dell’attività del pensiero. Una trasformazione, tuttavia, che supera il tempo nella stessa misura in cui ne rende visibile la qualità storica. (shrink)

1. Premesse Questo articolo richiede alcune premesse. Innanzitutto sono opportuni due chiarimenti, o precisazioni, che riguardano il titolo, Il nominalismo di Quine: un argomento circolare. Il primo chiarimento riguarda l’attribuzione a Willard Van Orman Quine di una posizione nominalistica, attribuzione contestabile sotto diversi rispetti. È vero che Quine è comunemente considerato uno dei maggiori esponenti del nominalismo contemporaneo. Tuttavia il termine “nominalismo” può essere inteso i...

Il cinquantennio a cavallo tra '200 e '300 rappresenta il periodo più stimolante e creativo per la riflessione sul rapporto tra necessità e contingenza e tra intelletto e volontà. L'A. analizza la difesa compiuta da Giovanni della tesi scotista sulla contingenza della fruizione beatifica, ossia sulla possibilità che il beato, in presenza della stessa essenza divina, possa mantenere la propria capacità di scelta, al punto tale da poter essere in grado di non abbandonarsi all'amore verso di Dio. Prima di analizzare (...) in modo più dettagliato il pensiero del Reading, l'A. passa in rassegna le posizioni di Duns Scoto, Roberto Cowton, Riccardo di Conington, Guglielmo d'Occam, Pietro Aureolo che, in terra francese, diversamente da Francesco di Meyronnes e Giovanni di Bassoles, non aderì alla tesi scotista della contingenza della fruizione. All'interno di questo programma teorico Reading si oppone innanzitutto ai teologi inglesi che, legati a posizioni tradizionali, sostenevano la necessità in via come in patria della fruizione del sommo bene colto come concetto o contemplato come essenza. In appendice vien pubblicata l'ed. della sesta quaestio della prima distinctio del Commento alle Sentenze di Giovanni Reading basata sul ms. Firenze, B.N.C., Conv. Soppr. D IV 95. (shrink)